The Misandrists begin with Volker, a young man with an injured leg, stumbling through the forest, pursued by the police and their tracking dogs. When he emerges from the woods, he sees two young women, Isolde and Hilde, frolicking in a field not far from a large old country house. When the beautiful young Isolde realizes that the handsome young man is in trouble with the law, she convinces Hilde to help her hide him in the basement of the house, which happens to be a school for wayward girls. Isolde forces Hilde to agree to keep the young man's presence in the basement hidden from the rest of the household, especially from Big Mother, who runs the school, which is comprised of twelve other females: four teachers and eight young women rescued from the streets. It is a lesbian separatist stronghold. Isolde secretly nurses Volker back to health, but does not let him know that the school for girls is also a front for a quasi-terrorist organization called the FLA - the Female Liberation.
Set in the post-AIDS future of 2060, where the Government is the first to declare the era AIDS free, mutated AIDS viruses give birth to zero gen - humans that have genetically evolved in a very unique way. These gender fluid zero gens are the bio-drug carriers whose white fluid is the hyper-narcotic for the 21st century, taking over the markets of the 20th century white powder high. The ejaculate of these beings is intoxicating and the new form of sexual commodity in the future. The new drug, code named delta, diffuses through skin contact and creates an addictive high. A new war on drugs begins and the zero gen are declared illegal. The Government dispatches drug-resistant replicants for round-up arrest missions. When one of these government android's immunity breaks down and its pleasure centres are activated, the story becomes a tangled multi-thread plot and the zero gens are caught among underground drug lords, glitched super agents, a scheming corporation and a corrupt government.
Berlin-Kreuzberg is Nora's microcosm. Nora, the silent observer, is always tagging along: At parties, at school, at the pool, on rooftops and in apartments. Nora drifts around the monotonous housing blocks with her big sister and her friends, witnessing events that seem to cross-fade in the summer light. Girls who want to be slim and pretty, boys who say dumb things to provoke or because they are in love. Ruthless smartphone cameras and fragile teenagers. But Nora has her own way of looking at the world, and when she meets Romy, she realizes why. There is music in the air, Nora's body is changing, and caterpillars are spinning their cocoons. Realistic and taking on the protagonist's perspective, this film captures a summer of change.